Increased substantia nigra echogenicity in LRRK2 family members without mutations
نویسندگان
چکیده
منابع مشابه
Echogenicity of the substantia nigra region in Parkinson's disease.
Hospital das Clínicas, University of São Paulo School of Medicine (FMUSP), São Paulo, Brazil. Correspondence: Edson Bor-Seng-Shu; Divisão de Cirurgia Neurológica, Hospital das Clínicas, USP; Avenida Dr. Eneas de Carvalho Aguiar 255; 05403-000 São Paulo SP Brasil; E-mail: [email protected] Conflict of interest: There is no conflict of interest to declare. Received 04 September 2011; Received ...
متن کاملEchogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury.
BACKGROUND Patients with Parkinson disease characteristically exhibit an increased echogenicity of the substantia nigra (SN) on transcranial sonography, a new neuroimaging technique. The same echo feature of the SN can be identified in 9% of healthy adults. OBJECTIVE To evaluate the relevance of the echogenic SN in healthy adults. DESIGN In the first part of the study, 10 healthy subjects y...
متن کاملRelationship of substantia nigra echogenicity and motor function in elderly subjects.
BACKGROUND Patients with Parkinson's disease (PD) exhibit an increased echogenicity of the substantia nigra (SN) on transcranial sonography. Some healthy adults with the same echo characteristics showed a reduced 18fluorodopa uptake on PET, indicating a subclinical alteration of the nigrostriatal system. OBJECTIVES To determine whether the sonographic phenotype of hyperechogenic SN has any re...
متن کاملIncreased dopamine synthesis in aging substantia nigra neurons.
Striatal dopamine (DA) and metabolite (DOPAC) levels in 8-, 21-, 52- and 104-week-old C57BL mice were compared with those in 11-week-old mice, 20 days after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment. DA and DOPAC concentrations expressed relative to striatal wet weight did not change with age. In contrast, DA and DOPAC levels increased almost linearly when values were expres...
متن کاملDifferential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents.
Mutations in leucine-rich repeat kinase 2 (LRRK2) are found in a significant proportion of late-onset Parkinson's disease (PD) patients. Elucidating the neuroanatomical localization of LRRK2 will further define LRRK2 function and the molecular basis of PD. Here, we utilize recently characterized monoclonal antibodies to evaluate LRRK2 expression in rodent brain regions relevant to PD. In both m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Movement Disorders
سال: 2018
ISSN: 0885-3185
DOI: 10.1002/mds.27443